A multidisciplinary observational data platform
The ARSIA Project is a structured initiative led by ARSIA to implement a multidisciplinary longitudinal observational study on regenerative surgery.
The ARSIA Project is a structured initiative led by ARSIA to implement a multidisciplinary longitudinal observational study on regenerative surgery.
The project includes the creation of a secure digital registry, the organization of clinical and technical training, and the integration of hospital teams (surgeons, nurses, researchers) within a standardized protocol. With an initial target of 100 documented cases, the project is supported by a young surgeons task force and centralized documentation, aiming for academic recognition through publications and integration into university diplomas.
Dr Gabriel Saiydoun
Vice-President of ARSIA
Dr. Saiydoun plays a key role in integrating scientific data from regenerative practices into clinical protocols and in developing a dedicated observational data platform.
Dr Jean-Claude Couffinhal
Vice-President of ARSIA
Dr. Couffinhal is actively involved in shaping the scientific governance of regenerative surgery and establishing clinical data standards for international consensus.
Autologous Platelet-Rich Plasma for Mediastinitis Prevention: A Randomized Controlled Trial in Isolated CABG Patients
Dr. Gabriel Saiydoun – Prof. Pascal Leprince
Cardiac and Vascular Surgery
La Pitié Salpetrière Hospital – Sorbonne University
Study Objective
To evaluate the efficacy of intraoperative autologous PRP in the prevention of mediastinitis.
Study Design and Population
- Prospective Study
- Randomized
- Controlled
- Multicenter APHP
- October 2025 – January 2026
- Pitié-Salpêtrière University Hospital
- Coronary Bypass Grafts – Adults – History of Cardiac Surgery: Exclusion
Materials & Methods
Patient Groups
Control Group (Standard Closure):
100 patients – Conventional steel wires – No PRP application
PRP Group:
100 patients – Sternal closure with the same conventional steel wires – With intraoperative application of autologous PRP
Patient Groups
3 types of PRP prepared:
- RegenPRP™: Prepared using the RegenBCT tube and injected into the scar edges
- PRP Gel: Prepared using the Surgery Kit and applied to the sternum wound
- PRP Glue: Prepared using the ACR-C Plus (RegenBCT and RegenATS + Spray applicator) injected
into and onto the wound after suturing
Follow-up and Outcome Criteria
Primary Outcome Criteria: Incidence of mediastinitis and mediastinitis-related mortality
6 months
Secondary Outcomes independently assessed:
- Isolated incidence of mediastinitis
- Mediastinitis-related mortality
- All-cause mortality
- Sternal wound dehiscence or instability
- Length of hospital stay
- Reoperation rate
- Occurrence of bleeding complications